» Dr. Rakesh Tiwari
Assistant Professor

School of Pharmacy
Dr. Rakesh Tiwari
Office Location:
Rinker Health Science Campus 263
Phone:
(714) 516-5483
Email:
Education
University of Delhi, Bachelor of Science
University of Delhi, Master of Science
University of Delhi, Ph.D.
Biography

Dr. Rakesh Kumar Tiwari is currently an Assistant Professor of Biopharmaceutical and Biomedical Sciences. He joined CUSP in September 2013. He was an Assistant Professor in Department of Life Sciences at Shiv Nadar University in India for a short time. He received his Ph.D. (2006) in Organic Chemistry from Dr. B.R. Ambedker Center for Biomedical Research, University of Delhi, one of the most reputed Institutes and Universities in India. During his Ph.D. research work, he developed several new classes of antimicrobial compounds using indoles. After his Ph.D, he was awarded a prestigious and highly competitive Young Scientist Grant from Department of Science & Technology, Government of India. He became involved for the synthesis of a new class of DNA intercalating agents.

In 2007, Dr. Tiwari’s strong interest to conduct research in the area of application of chemistry in biology led him to pursue his postdoctoral research at Dr. Keykavous Parang’s laboratory in College of Pharmacy, University of Rhode Island. His postdoctoral work resulted in the synthesis of several peptide nanomaterials, kinase inhibitors as anticancer compounds, and many neuroprotective agents. Dr. Tiwari was awarded 2013 research excellence postdoctoral award from the University of Rhode Island. He was also a recipient of American Heart Association Postdoctoral Fellowship. He is a member of American Chemical Society, American Association of Pharmaceutical Scientists, American Association for Advancement of Science, and American Peptide Society.

Research Interests

Dr. Tiwari has a keen interest at the interphase of chemistry and biology with a focus on using peptides and small molecules in solving biological problems. Major areas of interest include developing CN2097 peptide analogs for neurotherapeutics, synthesizing fatty acyl derivatives of antibacterial peptides for MRSA, developing peptide-drug conjugates (PDC) for prostate cancer targeted therapy. Other areas of interest are optimizing dasatinib conjugates for developing specificity in protein kinases, peptide based drug delivery system, and development of new synthetic methodologies. Dr. Tiwari has authored 81 peer-reviewed articles, 1 patent, 1 book chapter, and 63 meeting abstracts.

For more information, please visit  http://sites.chapman.edu/tiwari/

Recent Creative, Scholarly Work and Publications
J. Marshall, J. Szmydynger-Chodobska, M.S Rioult-Pedotti, K. Lau, A. T. Chin, S. K. R. Kotla, R. K.Tiwari, K. Parang, S. W. Threlkeld, and A. Chodobski. TrkB-enhancer facilitates functional recovery after traumatic brain injury. Scientific Report (In Press), 2017. DOI: 10.1038/s41598-017-11316-8.
N. Riahifard, K. Tavakoli, J. Yamaki, K. Parang*, R. Tiwari*. Synthesis and Evaluation of Antimicrobial Activity of [R4W4K]-Levofloxacin and [R4W4K]-Levofloxacin-Q Conjugates. Molecules, 2017, 22(6). PMID: 28594345. DOI: 10.3390/molecules22060957.
S. Darwish, K. Parang, J. Marshall, D. J. Goebel, R. Tiwari*. Efficient synthesis of CN2097 using in situ activation of sulfhydryl group. Tetrahedron Letters, 2017, 58, 3053-3056. DOI: 10.1016/j.tetlet.2017.06.066.
M. Sharma, N.S. El-Sayed, H. Do, K. Parang, R. K. Tiwari* and H. Aliabadi*. Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates. Scientific Report (In Press), 2017. DOI: 10.1038/s41598-017-06381-y.
S. K. R. Kotla, J. K. Vandavasi, Jeh-Jeng Wang, K. Parang and R. K. Tiwari.* Palladium-catalyzed intramolecular cross-dehydrogenative coupling: synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]pyrimidines. ACS Omega, 2017, 2(1), 11–19. doi: 10.1021/acsomega.6b00417.
R. K. Tiwari,* A. Brown, A. N. Shirazi, J. Bolton, A. Tse, G. Verkhivker,* K. Parang,* and G. Sun*. Design, synthesis, and evaluation of dasatinib-amino acid and dasatinib-fatty acid conjugates as Protein Tyrosine Kinase Inhibitors. ChemMedChem, 2017, 12(1), 86-99. doi: 10.1002/cmdc.201600387. PMID: 27875633.
N.S. El-Sayed, A. N. Shirazi, M.G. El-Meligy, A.K. EL-Ziaty, Z.A. Nagieb*, K. Parang*, R. K. Tiwari*. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. International Journal of Biological Macromolecules, 2016, 87, 611-622. PMID: 26976071.
D. Weerakkody, A. Moshnikova, N. S. El-Sayed, R. C. Adochite, G. Slaybaugh, J. Golijanin, R. K. Tiwari, O.A. Andreev, K. Parang, Y. K. Reshetnyak. Novel pH-Sensitive Cyclic Peptides. Scientific Rep. 2016, 12(6), 31322. doi: 10.1038/srep31322. PMID: 27515582.
A. N. Shirazi, N.S. El-Sayed, D. Mandal, R. K. Tiwari, K. Tavakoli, M. Estesham, K. Parang. Cysteine and arginine-rich peptides as molecular carriers. Bioorg. Med. Chem. Lett. 2016, 26(2), 656-661. doi: 10.1016/j.bmcl.2015.11.052. PMID: 26631317.
S. Mokhtari. A. N. Shirazi, R. K. Tiwari, K. Parang, and Farzad Kobarfard. Synthesis of 3-Arylidene and 3-Arylimine Oxindole Derivatives and Evaluation of Their Src Kinase Inhibitory and Antiproliferative Activities. Medicinal Chemistry, 2015, 5(6), 242-252. doi: 10.4172/2161-0444.1000271.
K. Chand, R. K. Tiwari, S. Kumar, A. N. Shirazi, S. Sharma, E. V. V. D. Eycken, V. S. Parmar, K. Parang, and S. K. Sharma. Synthesis, antiproliferative, and c-Src kinase inhibitory, activities of 4-Oxo-4H-1-benzopyran derivatives. J. Heterocyclic Chemistry, 2015, 52, 562-572.
J. Marshall, K. Y. Wong, K. Parang, R. Tiwari, M. R. Spaller, C. N. Rupasinghe, E.D. Berberoglu, X. Zhao, C. Sinkler, J. Liu, I. Lee, M. Huttemann, and D. J. Goebel. Inhibition of NMDA-induced retinal neuronal death by polyarginine peptides is linked to the attenuation of stress-induced hyperpolarization of the inner mitochondrial membrane potential. Journal of Biological Chemistry, 2015, 290(36), 22030-22048. doi: 10.1074/jbc.M115.662791).
M. Sharma, M. Tiwari, R. K. Tiwari. Hyperhomocysteinemia: Impact on Neurodegenerative Diseases. Basic Clin. Pharmacol. Toxicol. 2015 (Accepted in Press, doi: 10.1111/bcpt.12424).
S. K. R. Kotla, D. Choudhary, R. K. Tiwari, A. K. Verma. Rhodium(III)-catalyzed double C-H activation: A straightforward approach to fused imidazo[1,2-a]pyridines from internal alkynes. Tetrahedron Letters, 2015, 56(32), 4706-4710.
B. Ramos-Molina, A. N. Lick, A. N. Shirazi, D. Oh, R. Tiwari, N. S. El-Sayed, K. Parang, I. Lindberg. Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. PloS one. 2015; 10(6):e0130417.
R. K. Saunthwal, M. Patel, R. K. Tiwari, K. Parang and A. K. Verma. On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate. Green Chemistry, 2015, 17, 1434-1441.
B. P. Pemmaraju, S. Mallekar, H. K. Agarwal, R. K. Tiwari, D. Oh, G. F. Doncel, D. R. Worthen, K. Parang. Design, Synthesis, Antiviral Activity, and Pre-formulation Development of Poly-L-Arginine-Fatty acyl Derivatives of Nucleoside Reverse Transcriptase Inhibitors. Nucleosides, Nucleotides and Nucleic Acids. 2015, 34 (1), 1-15.
D. Oh, S. A. Darwish, A. N. Shirazi, R. K. Tiwari, and K. Parang. Amphiphilic Bicyclic Peptides as Cellular Delivery Agents. Chemmedchem, 2014, 9(11), 2449-2453.
N. Sayeh, A. N. Shirazi, D. Oh, J. Sun, D. Rowley, A. Banerjee, A. Yadav, R. K. Tiwari, and K. Parang. Amphiphilic Triazolyl Peptides: Synthesis and Evaluation as Nanostructures. Current Organic Chemistry, 2014, 18(20), 2665-2671.
A. N. Shirazi, R. Tiwari, D. Oh, B. Sullivan, A. Kumar, Y. Beni, and K. Parang. Cyclic Peptide-Selenium Nanoparticles as Drug Delivery Systems. Molecular Pharmaceutics, 2014, 11(10), 3631-3641.
D. Oh, A. N. Shirazi, K. Northup, B. Sullivan, R. K. Tiwari, M. Bisoffi, and K. Parang. Enhanced Cellular Uptake of Short Polyarginine Peptides through Fatty Acylation and Cyclization. Molecular Pharmaceutics, 2014, 11 (8), 2845–2854.
B. Pemmaraju, H. K. Agarwal, D. Oh, K. W. Buckheit, R. W. Buckheit Jr., R. Tiwari, K. Parang. Synthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors. Tetrahedron Letters, 2014, 55(12), 1983-1986.
K. Chand, S. Prasad, R. K. Tiwari, A. N. Shirazi, S. Kumar, K. Parang, and S. Sharma. Synthesis and Evaluation of c-Src Kinase Inhibitory Activity of Pyridin-2(1H)-one Derivatives. Bioorganic Chemistry, 2014, 53, 75-82.
S. Motavallizadeh, A. Fallah-Tafti, S. Maleki, A. N. Shirazi, M. Pordeli, M. Safavi, S. K. Ardestani, S. Asd, R. Tiwari, D. Oh, A. Shafiee, A. Foroumadi, K. Parang, and T. Akbarzadeh. Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tetrahedron Letters, 2014, 55, 373-375.
A. K. Verma, M. Patel, M. Joshi, P. R. Likhar, R. K. Tiwari, and K. Parang. Base-Mediated Chemo-and Stereoselective Addition of 5-Aminoindole/Tryptamine and Histamines onto Alkynes. Journal of Organic Chemistry, 2014, 79(1), 172-186.