» Dr. Miao Zhang
Assistant Professor

School of Pharmacy
Dr. Miao Zhang
Office Location:
Rinker Health Science Campus 297N
Phone:
714-516-5478
Email:
Biography
He earned his Ph.D. degree of Pharmaceutical Sciences from Kyoto University in 2007, followed by postdoctoral study in School of Medicine, Thomas Jefferson University.

Dr. Zhang’s group utilizes structural biology techniques to study ion channel pharmacology. Specific areas currently under investigation include (1) Molecular overlap in the modulation of SK channels by the small molecules and phosphinositides; (2) Structure based drug discovery for SK channels. He is an author of 11 peer-reviewed publications on high impact journals such as Nature Chemical Biology, PNAS and Nature Communications.

Dr. Zhang is a member of Biophysical Society, Society for Neuroscience, American Association for the Advancement of Science and American Heart Association. Dr. Zhang’s research is currently funded by National Center of American Heart Association and National Ataxia Foundation.

Research Interests

Dr. Zhang’s group utilizes structural biology techniques to study ion channel pharmacology. Specific areas currently under investigation include (1) Molecular overlap in the modulation of SK channels by small molecules and phosphinositides; (2) Structure based drug discovery for SK channels. He is an author of 14 peer-reviewed publications and 10 meeting abstracts.

Selective Publications

Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF.  Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex.Nature Chemical Biology. 2014 Sep 10(9):753-9.

Mahajan R, Ha J, Zhang M, Kawano T, Kozasa T, Logothetis DE.  A Computational Model Reveals the Action of Gβγ at an Inter-Subunit Cleft to Activate GIRK1 Channels. Science Signaling. 2013 Aug 13; 6 ra69. (Selected as Cover for the issue)

Zhang M, Pascal JM, Zhang JF.  Unstructured to structured transition of an intrinsically disordered protein fragment in coupling Ca2+-sensing and SK channel activation.Proc Natl Acad Sci USA. 2013 Mar 19;110(12):4828-33.

Zhang M, Pascal JM, Schumann M, Armens RS, Zhang JF.  Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels.Nature Communications. 2012 Aug 28;3:1021.

Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF.  Structural basis for calmodulin as a dynamic calcium sensor.  Structure (Cell Press). 2012 May 9;20(5):911-23.

Zhang M, Yamazaki T, Yazawa M, Treves S, Nishi M, Murai M, Shibata E, Zorzato F, and Takeshima H.  Calumin, a novel Ca2+-binding protein on the endoplasmic reticulum.  Cell Calcium. 2007 Jul;42(1):83-90.Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin PH, Pan Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J, Takeshima H.  TRIC channels are essential for Ca2+ handling in intracellular stores.  Nature. 2007 Jul 5;448(7149):78-82.

Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H.  Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice.  J Biol Chem. 2005 Feb 4;280(5):3500-6.

 

Recent Creative, Scholarly Work and Publications
Brown BM, Shim H, Zhang M, Yarov-Yarovoy, V, Wulff H. Structural determinants for the selectivity of the positive KCa3.1 gating modulator 5- methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Molecular Pharmacology. July 31, 2017, mol.117.109421.
Logothetis DE, Petrou VI, Zhang M, Mahajan R, Meng XY, Adney SK, Cui M, Baki, L. Phosphoinositide control of membrane protein function: a frontier led by studies on ion channels. Annu Rev Physiol. 2015; 77:10.1-10.24.
Zhang M*, Meng XY, Zhang JF, Cui M, Logothetis DE*. Molecular overlap in the regulation of SK channels by small molecules and phosphoinositides. Science Advances. 2015 Jul e1500008.
Cui M, Qin G, Yu K, Bowers MS, Zhang M. Targeting the Small- and Intermediate-Conductance Ca2+-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface. Neurosignals. 2014; 22:65-78.
Zhang M, Meng XY, Cui M, Pascal JM, Logothetis DE, Zhang JF. Selective phosphorylation modulates the PIP2 sensitivity of the CaM-SK channel complex. Nature Chemical Biology. 2014 Sep 10(9):753-9.
Mahajan R, Ha J, Zhang M, Kawano T, Kozasa T, Logothetis DE. A Computational Model Reveals the Action of Gß at an Inter-Subunit Cleft to Activate GIRK1 Channels. Science Signaling. 2013 Aug 13; 6 ra69. (Selected as Cover for the issue)
Zhang M, Pascal JM, Zhang JF. Unstructured to structured transition of an intrinsically disordered protein fragment in coupling Ca2+-sensing and SK channel activation. Proc Natl Acad Sci USA. 2013 Mar 19;110(12):4828-33.
Zhang M, Pascal JM, Schumann M, Armens RS, Zhang JF. Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels. Nature Communications. 2012 Aug 28;3:1021.
Zhang M, Abrams C, Wang L, Gizzi A, He L, Lin R, Chen Y, Loll PJ, Pascal JM, Zhang JF. Structural basis for calmodulin as a dynamic calcium sensor. Structure (Cell Press). 2012 May 9;20(5):911-23.