» Dr. Kamaljit Kaur
Associate Professor

School of Pharmacy
Dr. Kamaljit Kaur
Office Location:
Rinker Health Science Campus 210
Phone:
(714) 516-5494
Email:
Website:
http://sites.chapman.edu/kaur/
Education
University of Delhi, Bachelor of Science
Indian Institute of Technology, Master of Science
Case Western Reserve University, Ph.D.
Biography

Dr. Kamaljit Kaur is an Associate Professor of Targeted Drug Delivery and Biomedical Diagnostics at the School of Pharmacy of Chapman University.

Dr. Kaur received her PhD (1999) in Bioorganic Chemistry from Case Western Reserve University, Cleveland, Ohio, where the topic of her thesis was low density lipoprotein (LDL) oxidation.  Following her Ph.D., she accepted a postdoctoral position at Wesleyan University (Connecticut), where she worked on design of antibacterial agents targeted toward penicillin resistant bacteria.  She accepted a second postdoctoral position in the Department of Chemistry at the University of Alberta to work on antimicrobial peptides.  Subsequently Dr. Kaur joined the Faculty of Pharmacy and Pharmaceutical Sciences at the University of Alberta (Edmonton, Canada) as an Assistant Professor, and was tenured and promoted to an Associate Professor in 2012.  In 2015, she joined Chapman University to lead a globally acclaimed research program in Targeted Drug Delivery and Biomedical Diagnostics.

During her academic career, Dr. Kaur has taught several courses in medicinal chemistry, drug delivery and bioanalytical techniques at the undergraduate and graduate levels.  She has served on the review panel of several granting agencies, such as Canadian Institutes of Health Research (CIHR) and Canadian Breast Cancer Foundation (CBCF) and has served as a reviewer for more than 25 journals.  She has published 47 peer reviewed articles, 3 book chapters, been listed as an inventor in 1 approved patent, and has presented 20 invited talks.

Research Interests

Dr. Kaur’s research has evolved into two main programs:

(i)             Targeted Drug Delivery

Her research program in “Targeted Drug Delivery” involves engineering cancer targeting peptides for increased therapeutic efficacy of current chemotherapeutic drugs, and development of peptide-drug conjugates (PDCs). 

(ii)           Biomedical Diagnostics

Her research program in “Biomedical Diagnostics” involves design, synthesis, and development of peptide-based biosensor platforms as diagnostics for pathogenic bacteria and circulating tumor cells.

 

Selected Publications

Targeted Drug Delivery

R. Soudy, C. Chen, and K. Kaur*, Novel Peptide-Doxorubicin Conjugates for Targeting Breast Cancer Cells including the Multidrug Resistant Cells, J. Med. Chem.,2013, 56, 7564-7573.

R. Soudy, A. Gill, T. Sprules, A. Lavasanifar, and K. Kaur*, Proteolytically Stable Cancer Targeting Peptides with High Affinity for Breast Cancer Cells, J. Med. Chem., 2011, 54, 7523-7534.

S. Ahmed, A.S. Mathews, N. Byeon, A. Lavasanifar, K. Kaur*, Peptide Arrays for Screening Cancer Specific Peptides. Anal. Chem.,2010, 82, 7533-7541.

 

Biomedical Diagnostics

S. Azmi, K. Jaing, T. Thundat, K. Kaur*, Detection of Listeria monocytogenes with short peptide fragments from class IIa bacteriocins as recognition elements, ACS Comb. Sci.,2015, 17, 156-163.

H. Etayash, K. Jaing, T. Thundat, K. Kaur*, Impedimetric Detection of Pathogenic Gram-Positive Bacteria using An Antimicrobial Peptide from Class IIa Bacteriocins, Anal. Chem., 2014, 86, 1693-1700.

R. Soudy, L. Wang, and K. Kaur*, Synthetic Peptides derived from the Sequence of a Lasso Peptide Microcin J25 show Antibacterial Activity, Bioorg. Med. Chem., 2012, 20, 1794-1800.

Recent Creative, Scholarly Work and Publications
H. Etayash, T. Thundat, K. Kaur*, Bacterial Detection using Peptide-based Platform and Impedance Spectroscopy, in Methods Mol. Biol., Biosensors and Biodetection: Methods and Protocols, Second Edition, Edited by Avraham Rasooly and Ben Prickril, 2017, Vol 1572, 113-124.
R. Soudy, A. Patel, W. Fu, K. Kaur, D. MacTavish, D. Westaway, R. Davey, J. Zajac, J. Jhamandas*, Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer’s Disease, Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2017, 3, 44-56.
P.M. Shaibani, H. Etayash, S. Naicker, K. Kaur, T. Thundat*, Metabolic Study of Cancer Cells using a pH Sensitive Hydrogel Nanofiber Light Addressable Potentiometric Sensor (NF-LAPS), ACS Sens. 2017, 2, 151-156.
R. Soudy, H. Etayash, K. Bahadorani, A. Lavasanifar, K. Kaur*, Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer, Mol. Pharm., 2017, 14, 593-604.
Y. Raghuwanshi, H. Etayash, R. Soudy, I. Paiva, A. Lavasanifar, K. Kaur*, Proteolytically stable cyclic decapeptide for breast cancer cell targeting, J. Med. Chem. 2017, 60, 4893-4903.
Jack Jhamandas, Rania Soudy, Kamaljit Kaur, When Fu, David, Mactavish, Aarti Patel, Brain Penetrant Amylin Receptor Based Peptides for Alzheimer’s Disease, U.S. Patent Application No. 62/396,370 filed May 2017.
R. Soudy, N. Byeon, Y. Raghuwanshi, S. Ahmed, A. Lavasanifar, K. Kaur, Engineered Peptides for Applications in Cancer Targeted Drug Delivery and Tumor Detection, Mini Rev. Med. Chem., 2016, 16.
K. Kaur, O. Tarassova, R.V. Dangeti, S. Azmi, D. Wishart, L. McMullen, M. Stiles, Characterization of a highly potent antimicrobial peptide microcin N from Uropathogenic Escherichia coli, FEMS Microbiol. Lett.
H. Etayash, A.R. McGee, K. Kaur, T. Thundat*, Nanomechanical sandwich assay for multiple cancer biomarkers in breast cancer cell-derived exosomes, Nanoscale 2016, 15137.
H. Etayash, M.F. Khan, K. Kaur*, T. Thundat*, Microfluidic cantilever detects bacteria and measures their susceptibility to antibiotics in small confined volumes, Nature Comm. 2016, 7, 12947.
K. Kaur, S. Ahmed, R. Soudy, S. Azmi, Screening Peptide Array Library for the Identification of Cancer Cell Binding Peptides in Methods Mol. Biol., Peptide Libraries, Edited by R. Derda, Springer, 2015, Vol 1248, 239-247.
H. Trzeciakiewicz, J. Esteves-Villanueva, R. Soudy, K. Kaur, S. Martic-Milne, Electrochemical Characterization of Protein Adsorption onto YNGRT-Au and VLGXE-Au Surfaces, Sensors, 2015, 15, 19429-19442.
H. Etayash, S. Azmi, R. Dangeti, K. Kaur, Peptide Bacteriocins – Structure Activity Relationships, Curr. Top. Med. Chem., 2015, 16, 220-241.
K. Jiang, H. Etayash, S. Azmi, S. Naicker, M. Hassanpourfard, P.M. Shaibani, G. Thakur, K. Kaur, T. Thundat, Rapid Label-free Detection of E. coli using Antimicrobial Peptide Assisted Impedance Spectroscopy, Anal. Methods, 2015, 7, 9744-9748.
H. Etayash, K. Jaing, S. Azmi, T. Thundat, K. Kaur, Real-time Detection of Breast Cancer Cells Using Peptide-functionalized Microcantilever Arrays, Sci. Rep. (Nature Publishing Group), 2015, 5, 13967:1-13.
M. H. Gilzad-Kohan, K. Kaur, and F. Jamali, Synthesis and characterization of a new peptide prodrug of glucosamine with enhanced gut permeability, PLoS One, 2015, 10(5), e0126786.
S. Azmi, K. Jaing, T. Thundat, K. Kaur, Detection of Listeria monocytogenes with short peptide fragments from class IIa bacteriocins as recognition elements, ACS Comb. Sci., 2015, 17, 156-163.
K. Kaur, S. Bhattacharjee, R. Pillai, S. Ahmed, S. Azmi, Peptide Arrays for Detecting Naphthenic Acids in Oil Sands Process Affected Water, RSC Advances, 2014, 4, 60694-60701.