Ren Ostrom

Dr. Rennolds Ostrom

Professor; Dean of the School of Pharmacy
Pharmacy, School of Pharmacy
Expertise: G Protein-Coupled Receptors; Cell Signaling; Second Messengers; Cell Physiology; Lung Diseases
Office Location: 9401 214
Education:
Dartmouth College, Bachelor of Arts
University of California, Irvine, Ph.D.

Biography

Dr. Rennolds Ostrom is Dean and Professor of Pharmacology at the Chapman University School of Pharmacy. Dr. Ostrom graduated with a B.A. in Biology from Dartmouth College and then earned a Ph.D. in Pharmacology from the University of California, Irvine. He has held faculty positions at the University of California, San Diego and the University of Tennessee medical schools before joining the faculty at Chapman in 2016. 

Dr. Ostrom is an internationally recognized expert in adenylyl cyclases and cAMP signaling, whose research has been continuously funded by the NIH since 2003. He has published over 80 peer-reviewed publications, review articles and book chapters as well as over 70 meeting abstracts. Dr. Ostrom serves as Associate Editor or editorial board member for several journals, including the British Journal of Pharmacology, Molecular Pharmacology and the American Journal of Physiology, Cell Physiology.

Recent Creative, Scholarly Work and Publications

Isabella Cattani-Cavalieri, Jordyn Margolis, Camelia Anicolaesei, Francisco J. Nuñez, and Rennolds S Ostrom. Real-time cAMP dynamics in live cells using the fluorescent cAMP Difference Detector In Situ. J Vis Exp, 22(205):10.3791/66451, 2024.
Isabella Cattani-Cavalieri, Hoeke A. Baarsma, Asmaa Oun, Christina H.T.J. van der Veen, Emily Oosterhout, Amalia Dolga, Rennolds S Ostrom, Samuel dos Santos Valenca, and Martina Schmidt. Diesel exhaust particles alter cAMP producing capacity and mitochondrial bioenergetics in human bronchial epithelial cells. Frontiers in Toxicology, DOI: 10.3389/ftox.2024.1412864.
Isabella Cattani-Cavalieri and Rennolds S Ostrom. One more negative regulator of AC6: S-nitrosylation. Am J Respir Cell Mol Biol, DOI: 10.1165/rcmb.2024-0350ED.
Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy Bogard, Moom R. Roosan and Rennolds S Ostrom. Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells. Frontiers in Physiology, 14:1-13, 2023.
Ajay Nayak, Elham Javed, Dominic Villalba, Yinna Wang, Henry Morelli, Sushrut Shaw, Nicholas Kim, Rennolds S Ostrom, Reynold Panettieri, Steven An, Dale Tang and Raymond Penn. Pro-relaxant EP receptors functionally partition to different pro-contractile receptors in airway smooth muscle. Am J Respir Cell Mol Biol, 69(5):584-591, 2023.
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong Elena Faccenda, Simon D Harding, Jamie A Davies, Stephanie Annett, Detlev Boison Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch , Nuala Ann Helsby, Angelo A Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes-Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong. The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Brit J Pharmacol, 180:S289-S373, 2023.
Katrina F. Ostrom, Justin E. LaVigne, Tarsis F. Brust, Roland Seifert, Carmen W. Dessauer, Val J. Watts and Rennolds S Ostrom. Physiological roles of mammalian transmembrane adenylyl cyclase isoforms. Physiological Reviews, 102(2): 815-57, 2022.
Tarsis F. Brust, Rennolds S Ostrom and Val J. Watts. Editorial: Adenylyl Cyclase Isoforms as Potential Drug Targets. Frontiers in Pharmacology, 13:1098240, 2022.
Carmen W. Dessauer, Rennolds S Ostrom, Roland Seifert, Val J. Watts. Adenylyl cyclases. The Concise Guide to Pharmacology 2021/22: Enzymes (edited by SP Alexander et. al.). Br J Pharmacol, 178 Suppl 1:S313-S411, 2021.
Yue Li, Ashely Duche, Michael Sayer, Don Roosan, Farid Khalafalla, Rennolds S Ostrom, Jennifer Totonchy, Moom R. Roosan. SARS-CoV-2 Early Infection Signature Identified Potential Key Infection Mechanisms and Drug Targets. BMC Genomics, 22(1):125, 2021.
Simeng Zhu, Shiqian Huang, Guofang Xia, Jin Wu, Yan Shen, Ying Wang, Rennolds S Ostrom, Ailian Du, Chengxing Shen, and Congfeng Xu. Anti-inflammatory effects of CHRNA7 through interacting with adenylyl cyclase 6. Br J Pharmacol,178(11):2324-2338, 2021.
Martina Schmidt, Isabella Cattani-Cavalieri, Francisco J. Nuñez and Rennolds S Ostrom. Phosphodiesterase isoforms and cAMP compartments in the development of new therapies for obstructive pulmonary diseases. Curr Opinion in Pharmacol, 51:34-42, 2020.
Cynthia Koziol-White, Timothy B. Johnstone, Maia L. Corpuz, Rennolds S Ostrom, Gaoyuan Cao, Sarah Orfanos, Vishal Parikh, Brian Deeney, Omar Tliba, Ian Dainty, Anna Miller-Larsson, Reynold A. Panettieri, Jr. Budesonide enhances agonist-induced bronchodilation in human small airways by rapidly increasing cAMP production in human airway smooth muscle. Am J Physiol, Lung Cell Mol Physiol, 318(2):L345-L355, 2020.
Reynold A. Panettieri, Yassine Amrani, Cynthia Koziol-White, Rennolds S Ostrom and Omar Tliba. Non-Genomic Effects of Glucocorticoids: An Updated View. Trends Pharmacol Sci, 40(1):38-49, 2019.
Christie A. Ojiaku, Elena Chung, Vishal Parikh, Jazmean K. Williams, Anthony Schwab, Ana Lucia Fuentes, Maia L. Corpuz, Victoria Lui, Sam Paek, Natalia M. Bexiga, Shreya Narayan, Francisco J. Nunez, Kwangmi Ahn, Rennolds S. Ostrom, Steven S. An and Reynold A. Panettieri, Jr. TGF-ß1 Decreases ß2-Agonist-Induced Relaxation in Human Airway Smooth Muscle. Am J Respir Cell Mol Biol, 61(2):209-18, 2019.
Rinzhin T. Sherpa, Ashraf M. Mohieldin, Rajasekharreddy Pala, Dagmar Wachten, Rennolds S Ostrom, Surya M. Nauli. Sensory primary cilium is a responsive cAMP compartment distinct from the cell body. Scientific Reports, 9(1):6523, 2019.
Shailesh R. Agarwal, Chase Fiore, Kathryn Miyashiro, Rennolds S Ostrom, and Robert D. Harvey. Effect of adenylyl cyclase type 6 on localized production of cAMP by ß2-adrenergic receptors in human airway smooth muscle cells. J Pharmacol Exp Thera,370(1):104-110, 2019.
Timothy B. Johnstone, Shailesh R. Agarwal, Robert D. Harvey and Rennolds S Ostrom. cAMP Signaling Compartmentation:?Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. Mol Pharmacol, 93(4):270-276, 2018.
Timothy B. Johnstone, Kaitlyn H. Smith, Cynthia J. Koziol-White, Fengying Li, Austin G. Kazarian, Maia L. Corpuz, Maya Shumyatcher, Frederick J. Ehlert, Blanca E. Himes, Reynold A. Panettieri, Jr. and Rennolds S Ostrom. PDE8 is expressed in human airway smooth muscle and selectively regulates cAMP signaling by ß2AR-AC6. Am J Respir Cell Mol Biol, 58(4):530-541, 2018.
Marwa M. Qadri, Ling X. Zhang, Rennolds S Ostrom, Gregory D. Jay and Khaled A. Elsaid. cAMP Attenuates TGF-ß’s Profibrotic Response in Osteoarthritic Synovial Fibroblasts: Involvement of PRG4 and Hyaluronan. Am J Physiol, Cell Physiol, 315(3):C432-C443, 2018.
Mavanoor R Nagaraja, Nivedita Tiwari, Shwetha K Shetty, Amarnath S Marudamuthu, Liang Fan, Rennolds S Ostrom, Jian Fu, Venkadesaperumal Gopu, Steven Idell and Sreerama Shetty. p53 expression in lung fibroblasts is linked to mitigation of fibrotic lung remodeling. Am J Pathology, Oct;188(10):2207-2222, 2018.
Shailesh R. Agarwal, Rennolds S Ostrom and Robert D. Harvey. Membrane microdomains and cAMP compartmentation in Cardiac Myocytes. Cardiac and Vascular Biology: Microdomains of the Cardiovascular System, Viacheslav Nikolaev and Manuela Zaccolo (editors), Springer Nature, 2017.
Shailesh R. Agarwal, Kathryn Miyashiro, Htun Latt, Rennolds S Ostrom, and Robert D. Harvey. Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells. Br J Pharmacol, doi: 10.1111/bph.13904, 2017.
Carmen W. Dessauer, Rennolds S Ostrom, Val J. Watts, Marco Conti, Clemens Steegborn, Stefan Dove and Roland Seifert. International Union of Basic and Clinical Pharmacology: Structures and Small Molecule Inhibitors of Mammalian Adenylyl Cyclases. Pharmacological Reviews, 69(2):93-139, 2017.

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