Dr. Rennolds Ostrom
- Dartmouth College, Bachelor of Arts
University of California, Irvine, Ph.D.
Dr. Rennolds Ostrom joined CUSP in 2016 as a Professor of Pharmacology. Dr. Ostrom graduated with a B.A. in Biology from Dartmouth College in 1990. He then worked in neuropharmacology at the University of Southern California School of Pharmacy and behavioral pharmacology for a start-up pharmaceutical company before entering graduate school. Dr. Ostrom earned a Ph.D. in Pharmacology from the University of California, Irvine in 1998.
As a graduate student, Dr. Ostrom studied muscarinic receptor signaling in airway and GI smooth muscle. He was awarded a UC Regents dissertation fellowship and an award for outstanding graduate student. Dr. Ostrom did postdoctoral training in the Department of Pharmacology at the University of California, San Diego. Here, he turned his focus to molecular pharmacology and began to unravel some of the earliest observations of GPCR signaling compartments. The American Heart Association named him a finalist for the prestigious Katz Award for outstanding young scientist.
Dr. Ostrom began his independent research career as an assistant professor at the University of Tennessee Health Science Center in 2003. That year he was awarded an R01 from NHLBI to study cAMP signaling in cardiac fibroblasts. In 2005 Dr. Ostrom was awarded an American Heart Association grant-in-aid to characterize the molecular determinants of adenylyl cyclase localization. In 2006 he was awarded an R01 from NHLBI to study cAMP signaling in airway and GI smooth muscle. Rising to Associate Professor in 2009, Dr. Ostrom began to shift toward dissecting the molecular details of cAMP signaling compartmentation. In 2014 he was funded by the American Heart Association for a phosphoproteomic study of cAMP signaling and in 2015 received an R01 to study human airway smooth muscle cAMP compartments from NIGMS.
Dr. Ostrom is an internationally recognized expert in adenylyl cyclases and cAMP signaling. He has published over 50 peer-reviewed publications, review articles and book chapters as well as over 60 meeting abstracts. He currently serves on the editorial board for the American Journal of Physiology, Cell Physiology and is Associate Editor for Naunyn-Schmiedeberg’s Archives of Pharmacology, the oldest pharmacology journal in existence.
Dr. Ostrom’s research seeks to understand how cells “pre-arrange” multiple signaling components in G protein couple receptor (GPCR) signal transduction cascades. Using expression of mutant signaling proteins, siRNA knockdown of native protein expression, and a variety of cell biological and biochemical approaches, Dr. Ostrom examines signaling mechanisms of GPCR. He is interested in the organization of cAMP signaling microdomains in the plasma membrane, especially in lipid raft/caveolin-rich regions. Various receptors, G-proteins and effectors, particularly adenylyl cyclase, localize in lipid rafts while others are excluded from these domains. The long-term focus of Dr. Ostrom’s research to understand how cAMP signaling compartments are formed and maintained, what components allow the cell to interpret these spatial signals differently, and how these features might be altered in disease. An understanding of these compartments and the cellular responses they mediate will lead to novel therapeutic strategies for cardiovascular disease, asthma, COPD and likely many other maladies.
Recent Creative, Scholarly Work and Publications
Reynold A. Panettieri, Yassine Amrani, Cynthia Koziol-White, Rennolds S Ostrom and Omar Tliba. Non-Genomic Effects of Glucocorticoids: An Updated View. Trends Pharmacol Sci, 40(1):38-49, 2019.
Christie A. Ojiaku, Elena Chung, Vishal Parikh, Jazmean K. Williams, Anthony Schwab, Ana Lucia Fuentes, Maia L. Corpuz, Victoria Lui, Sam Paek, Natalia M. Bexiga, Shreya Narayan, Francisco J. Nunez, Kwangmi Ahn, Rennolds S. Ostrom, Steven S. An and Reynold A. Panettieri, Jr. TGF-ß1 Decreases ß2-Agonist-Induced Relaxation in Human Airway Smooth Muscle. Am J Respir Cell Mol Biol, 61(2):209-18, 2019.
Rinzhin T. Sherpa, Ashraf M. Mohieldin, Rajasekharreddy Pala, Dagmar Wachten, Rennolds S Ostrom, Surya M. Nauli. Sensory primary cilium is a responsive cAMP compartment distinct from the cell body. Scientific Reports, 9(1):6523, 2019.
Shailesh R. Agarwal, Chase Fiore, Kathryn Miyashiro, Rennolds S Ostrom, and Robert D. Harvey. Effect of adenylyl cyclase type 6 on localized production of cAMP by ß2-adrenergic receptors in human airway smooth muscle cells. J Pharmacol Exp Thera,370(1):104-110, 2019.
Timothy B. Johnstone, Shailesh R. Agarwal, Robert D. Harvey and Rennolds S Ostrom. cAMP Signaling Compartmentation:?Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. Mol Pharmacol, 93(4):270-276, 2018.
Timothy B. Johnstone, Kaitlyn H. Smith, Cynthia J. Koziol-White, Fengying Li, Austin G. Kazarian, Maia L. Corpuz, Maya Shumyatcher, Frederick J. Ehlert, Blanca E. Himes, Reynold A. Panettieri, Jr. and Rennolds S Ostrom. PDE8 is expressed in human airway smooth muscle and selectively regulates cAMP signaling by ß2AR-AC6. Am J Respir Cell Mol Biol, 58(4):530-541, 2018.
Marwa M. Qadri, Ling X. Zhang, Rennolds S Ostrom, Gregory D. Jay and Khaled A. Elsaid. cAMP Attenuates TGF-ß’s Profibrotic Response in Osteoarthritic Synovial Fibroblasts: Involvement of PRG4 and Hyaluronan. Am J Physiol, Cell Physiol, 315(3):C432-C443, 2018.
Mavanoor R Nagaraja, Nivedita Tiwari, Shwetha K Shetty, Amarnath S Marudamuthu, Liang Fan, Rennolds S Ostrom, Jian Fu, Venkadesaperumal Gopu, Steven Idell and Sreerama Shetty. p53 expression in lung fibroblasts is linked to mitigation of fibrotic lung remodeling. Am J Pathology, Oct;188(10):2207-2222, 2018.
Shailesh R. Agarwal, Rennolds S Ostrom and Robert D. Harvey. Membrane microdomains and cAMP compartmentation in Cardiac Myocytes. Cardiac and Vascular Biology: Microdomains of the Cardiovascular System, Viacheslav Nikolaev and Manuela Zaccolo (editors), Springer Nature, 2017.
Shailesh R. Agarwal, Kathryn Miyashiro, Htun Latt, Rennolds S Ostrom, and Robert D. Harvey. Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells. Br J Pharmacol, doi: 10.1111/bph.13904, 2017.
Carmen W. Dessauer, Rennolds S Ostrom, Val J. Watts, Marco Conti, Clemens Steegborn, Stefan Dove and Roland Seifert. International Union of Basic and Clinical Pharmacology: Structures and Small Molecule Inhibitors of Mammalian Adenylyl Cyclases. Pharmacological Reviews, 69(2):93-139, 2017.