Dr. Rachita Sumbria

Dr. Rachita Sumbria

Associate Professor
School of Pharmacy
Office Location: Rinker Health Science Campus 94-297V
Phone: 714-516-5470
Education:
Institute of Chemical Technology, Bachelor of Technology
Texas Tech University, Ph.D.

Biography

Dr. Sumbria joined Chapman University School of Pharmacy as an Associate Professor in February of 2021. Dr. Sumbria received her PhD in Pharmaceutical Sciences from the Texas Tech University Health Sciences Center (TTUHSC) in 2010. At TTUHSC, her research centered on the development of intracerebral microdialysis as an experimental tool to study changes in the blood-brain barriers (BBB) permeability in ischemic stroke.

Dr. Sumbria completed her postdoctoral training at the Department of Medicine, blood-brain barrier laboratory at the University of California, Los Angeles and the Department of Neurology at the University of California, Irvine from 2011-2014. During her postdoctoral research at UCLA, Dr. Sumbria focused on the problem BBB bottleneck in CNS drug delivery. Particularly, her research focused on the use of receptor-mediated transcytosis for non-invasive delivery of biologics and other large molecular weight therapeutics across the BBB, and studying their pharmacologic effects in different experimental models of CNS disorders. At UCI, the focus of her research was studying the role of cerebral microbleeds in cerebrovascular diseases like stroke. In 2014, she joined the faculty at the School of Pharmacy and Health Sciences at the Keck Graduate Institute as an Assistant Professor and was promoted to Associate Professor in 2019. During her academic career, Dr. Sumbria has been extensively involved in research that has been funded by federal and foundation grants, teaching and mentoring laboratory research personnel and graduate students. 

Recent Creative, Scholarly Work and Publications

Chang R, Sumbria RK. Quantitative Evaluation of Cerebral Microhemorrhages in the Mouse Brain. Methods Mol Biol. 2023;2616:181-190.PMID: 36715935.
Fang, C., Lau, W.L., Sun, J., Chang R., Vallejo A., Lee D., Liu J., Liu H., Hung YH., Zhao Y., Paganini-Hill A., Sumbria RK., Cribbs DH., Fisher M. Chronic kidney disease promotes cerebral microhemorrhage formation. J Neuroinflammation 20, 51 (2023).
Yang, J.; Ou, W.; Jagadeesan, N.; Simanauskaite, J.; Sun, J.; Castellanos, D.; Cribbs, D.H.; Sumbria, R.K. The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy. Pharmaceuticals 2023, 16, 558.
Chandrashekar, D.V.; Steinberg, R.A.; Han, D.; Sumbria, RK. Alcohol as a Modifiable Risk Factor for Alzheimer’s Disease — Evidence from Experimental Studies. Int. J. Mol. Sci. 2023, 24, 9492.
Imran Sajid M, Sultan Sheikh F, Anis F, Nasim N, Sumbria RK, Nauli SM, Kumar Tiwari R. siRNA drug delivery across the blood-brain barrier in Alzheimer's disease. Adv Drug Deliv Rev. 2023 Aug;199:114968. Epub 2023 Jun 21. PMID: 37353152.
Zhang H$, Sumbria RK*$, Chang R$, Sun J, Cribbs DH, Holmes TC, Fisher MJ*, Xu X*. Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo. J Neuroinflammation 20, 265 (2023). $ first authors *corresponding authors
Ohno Y, Murphy R, Choi M, Ou W, Sumbria RK*. Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections. J. Vis. Exp. (183), e63669, doi:10.3791/63669 (2022).
Sun J, Ou W, Hill PA, Han D, Fisher MJ, Sumbria RK* Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport. PLOS One. 2022 May 25;17(5):e0268860. doi: 10.1371/journal.pone.0268860.
Feinberg PA, Becker SC, Chung L, Ferrari L, Stellwagen D, Anaclet C, Durán-Laforet V, Faust TE, Sumbria RK, Schafer DP*. Elevated TNF-a leads to neural circuit instability in the absence of Interferon Regulatory Factor 8. J Neurosci. 2022 Jul 1:JN-RM-0601-22. doi: 10.1523/JNEUROSCI.0601-22.2022.
Garcia J, Chang R, Steinberg RA, Arce A, Yang J, Van Der Eb P, Abdullah T, Chandrashekar DV, Eck SM, Meza P, Liu ZX, Cadenas E, Cribbs DH, Kaplowitz N, Sumbria RK, Han D*. Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-ß. Front Physiol. 2022 Sep 15;13:930402. doi: 10.3389/fphys.2022.930402. PMID: 36187787; PMCID: PMC9520570.
Ou W, Ohno Y, Yang J, Chandrashekar DV, Abdullah T, Sun J, Murphy R, Roules C, Jagadeesan N, Cribbs DH, Sumbria RK*. Efficacy and Safety of a Brain-Penetrant Biologic TNF-a Inhibitor in Aged APP/PS1 Mice. Pharmaceutics. 2022; 14(10):2200.
Sun J, Vyas P, Mann S, Paganini-Hill A, Nunes AC, Lau WL, Cribbs DH, Fisher MJ, Sumbria RK. Insights into the mechanisms of brain endothelial erythrophagocytosis. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.672009.
Yang J, Sumbria RK* The concentration of brain homogenates with the Amicon Ultra Centrifugal filters. MethodsX. 2021;8:101584.
Ou W, Yang J, Simanauskaite JM, Choi M, Castellanos DM, Chang R, Sun J, Jagadeesan N, Parfitt KD, Cribbs DH, Sumbria RK* Biologic TNF-a inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy. J Neuroinflammation. 2021;18:312
Sumbria RK. Targeting the transferrin receptor to develop erythropoietin for Alzheimer’s disease. Neural Regen Res. 2020;15(12):2251-2252.
Yang J, Sun J, Castellanos DM, Zambon AC, Pardridge WM, Sumbria RK. Eliminating Fc N-linked glycosylation and its impact on dosing consideration for a transferrin receptor antibody-erythropoietin fusion protein in mice. Mol Pharm. 2020 Aug 3;17(8):2831-2839.
Castellanos, D.M.; Sun, J.; Yang, J.; Ou, W.; Zambon, A.C.; Pardridge, W.M.; Sumbria RK. Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice. Pharmaceutics 2020, 12, 852.
Sun J, Martin JM, Vanderpoel V, Sumbria RK. The Promises and Challenges of Erythropoietin for Treatment of Alzheimer's Disease. Neuromol Med. 2019 Mar;21(1):12-24. PubMed PMID: 30656553; PubMed Central PMCID: PMC6407698.
Sun J, Boado RJ, Pardridge WM, Sumbria RK. Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice. Mol Pharm. 2019 Aug 5;16(8):3534-3543. PubMed PMID: 31199881; PubMed Central PMCID: PMC6684820.
Michael N, Grigoryan MM, Kilday K, Sumbria RK, Vasilevko V, van Ryn J, Cribbs DH, Paganini-Hill A, Fisher MJ. Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy. Front Neurol. 2019;10:966. PubMed PMID: 31611836; PubMed Central PMCID: PMC6776875
Sun J, Yang J, Whitman K, Zhu C, Cribbs DH, Boado RJ, Pardridge WM, Sumbria RK. Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice. Alzheimers Dement (N Y). 2019;5:627-636. PubMed PMID: 31660425; PubMed Central PMCID: PMC6807369.
Sumbria RK, Grigoryan MM, Vasilevko V, Paganini-Hill A, Kilday K, Kim R, Cribbs DH, Fisher MJ. Aging exacerbates development of cerebral microbleeds in a mouse model. J Neuroinflammation. 2018 Mar 6;15(1):69. PubMed PMID: 29510725; PubMed Central PMCID: PMC5840821.
Chang R, Castillo J, Zambon AC, Krasieva TB, Fisher MJ, Sumbria RK. Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds. Front Cell Neurosci. 2018;12:279. PubMed PMID: 30237761; PubMed Central PMCID: PMC6135875.
Chang R, Al Maghribi A, Vanderpoel V, Vasilevko V, Cribbs DH, Boado R, Pardridge WM, Sumbria RK. Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease. Mol Pharm. 2018 Nov 5;15(11):4963-4973. PubMed PMID: 30252487; PubMed Central PMCID: PMC6457666.
Chang R, Yee KL, Sumbria RK. Tumor necrosis factor a Inhibition for Alzheimer's Disease. J Cent Nerv Syst Dis. 2017 May 15;9:1179573517709278. PubMed PMID: 28579870; PubMed Central PMCID: PMC5436834.
Sumbria RK, Vasilevko V, Grigoryan MM, Paganini-Hill A, Kim R, Cribbs DH, Fisher MJ. Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages. J Neuroinflammation. 2017 Jun 5;14(1):114. PubMed PMID: 28583195; PubMed Central PMCID: PMC5460510.
Chang R, Knox J, Chang J, Derbedrossian A, Vasilevko V, Cribbs D, Boado RJ, Pardridge WM, Sumbria RK. Blood-Brain Barrier Penetrating Biologic TNF-a Inhibitor for Alzheimer's Disease. Mol Pharm. 2017 Jul 3;14(7):2340-2349. PubMed PMID: 28514851.

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