headshot photo of Dr. Marco Bisoffi

Dr. Marco Bisoffi

Associate Professor, Co-Program Director for the Faculty of Chemistry and Biochemistry
Schmid College of Science and Technology; Biological Sciences
Crean College of Health and Behavioral Sciences; Health Sciences
School of Pharmacy
Schmid College of Science and Technology; Chemistry
Expertise: Field Cancerization; Prostate Cancer; Tumor-Adjacent Tissues; Biomarker; Natural Products; Experimental cancer Therapeutics
Office Location: Keck Center for Science and Engineering 235
Phone: (714) 516-5961
Scholarly Works:
Digital Commons
University of Basel, Ph.D.

Video Profile


Dr. Bisoffi was originally trained in molecular and cell biology, and in biochemistry as applied to projects concerned with the molecular characterization of the cuticle of nematode parasites of human medical importance at the Swiss Tropical Institute of the Faculty of Natural Sciences at the University of Basel in Basel, Switzerland. This phase of his career included academic stays at the Imperial College of Science, Technology and Medicine, Department of Biochemistry in London, UK, and at the International Institute of Genetics and Biophysics in Naples, Italy.

After graduation, Dr. Bisoffi changed his field of research to molecular cancer research and underwent further post-doctoral training in the Department of Biochemistry and Molecular Biology of the University of New Mexico Health Sciences Center in Albuquerque, New Mexico, USA, at the Institute of Medical Microbiology of the University of Basel in Basel, Switzerland, in the Gene Chip Laboratory at Hoffmann-La Roche in Basel, Switzerland, and in the Department of Clinical Research of the University of Bern in Bern, Switzerland. His research during this time of his career was concerned with the molecular profiling of breast tumor vasculature, molecular mechanisms of prostate cancer progression, and the molecular mechanisms of carcinogenesis in mast cell tumors.

In 2002, Dr. Bisoffi became a Faculty Member in the Department of Biochemistry and Molecular Biology of the University of New Mexico Health Sciences Center in Albuquerque, New Mexico, USA. In this capacity he established several research programs focused on the molecular mechanisms underlying prostate and breast cancer, the discovery and validation of biomarkers of early and progressive disease in these two type of hormone-dependent solid tumors, as well as the screening, identification, and testing of natural product-based anti-prostate cancer organic small molecules and the elucidation of their mechanism of action. These projects were highly translational and included consented patient participation at the University of New Mexico Hospital and Cancer Center, and the Veterans Affairs Health Care System. Other projects included Dr. Bisoffi as an active collaborator in endeavors concerned with the development and use of targeted anti-prostate cancer nanoparticles and surface acoustic wave based pathogen biosensors.

In 2013, Dr. Bisoffi joined the Schmid College of Science and Technology at Chapman University as an Associate Professor of Biological Sciences, where he pursues some of the projects developed at the University of New Mexico (see Research Interests below).

Research Interests/Projects

  • Molecular mechanisms underlying “field cancerization” in human tissues affected by adenocarcinomas
  • Molecular mechanisms of prostate cancer progression to castration resistance
  • Natural product based experimental therapeutics with a focus on reactive oxygen species and target protein degradation


  • BCHM 335: Biochemistry I – Biomolecules
  • BCHM/BIOL 436: Molecular Genetics
  • BCHM/BIOL 401: Cancer Biology


  • American Association for Cancer Research
  • American Society for Biochemistry and Molecular Biology
  • Society for Basic Urologic Research
  • American Chemical Society

Editorial and Review Boards

  • Department of Defense Prostate Cancer Research Program
  • Department of Defense Breast Cancer Research Program
  • National Cancer Institute
  • Peer-reviewed journals, including: BioEssays, Cancers, Cancer Letters, Clinical Experimental Metastasis, Neoplasia, Bioorganic and Medicinal Chemistry Letters, PLoS, Journal of Cellular Biochemistry, Journal of Urology, Biosensors and Bioelectronics, The International Journal of Cancer, The International Journal of Oncology, Letters in Drug Design & Discovery, Genome Research, Molecular Carcinogenesis, Lancet Oncology, and others.

Recent Creative, Scholarly Work and Publications

Bisoffi M, O’Neill JM. Curcumin Analogs, Oxidative Stress, and Prostate Cancer; in OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS, 2nd edition (Preedy VR, Patel V, editors); Academic Press, Elsevier; 2021. ISBN-21: 978012819575.