Dr. Khaled Elsaid
- Cairo University, Bachelor of Science
University of Rhode Island, Master of Science
University of Rhode Island, Ph.D.
Dr. Khaled A. Elsaid joined CUSP on August 1st, 2016 as an associate professor of pharmacology. Dr. Elsaid graduated with a Bachelor of Science in Pharmaceutical Sciences from Cairo University in 1997. He traveled to the U.S. for his graduate education at the University of Rhode Island (URI) in 1999. Over a 6 year period (1999-2005), he earned an MS in Biomedical Sciences, a Ph.D. in Pharmacology and Toxicology and a Master’s in Business Administration (MBA). His research projects at URI included synthesis and characterization of biologically-active bactericidal peptides and studying the early markers of joint damage following an acute joint injury. After graduation, Dr. Elsaid worked as a research associate
As a clinician-scientist, Dr. Elsaid has active research programs in translational pharmacology and practice-based research.
Dr. Elsaid’s research in translational pharmacology focuses on developing interventions that address
Alquraini A, Garguilo S, D’Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA. The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluids. Arthritis Res Ther 2015; Arthritis Res Ther 2015;17:353.
Al-Sharif A, Jamal M, Zhang LX, Larson K, Schmidt TA, Jay GD, Elsaid KA. Lubricin/Proteoglycan 4 binding to
Elsaid KA, Zhang L, Shaman Z, Patel C, Schmidt TA, Jay GD. The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model. Osteoarthritis Cartilage 2015;23(1):114-21.
Elsaid KA, Ferreira L, Truong T, Liang A, Machan J, D’Souza GG. Pharmaceutical nanocarrier association with chondrocytes and cartilage explants: influence of surface modification and extracellular matrix depletion. Osteoarthritis Cartilage 2013;21:377-84.
Dr. Elsaid’s research interests in practice-based research
Migliozzi D, Zullo A, Collins C, Elsaid KA. Achieving blood pressure control among renal transplant recipients by integrating electronic health technology and clinical pharmacy services. Am J Health-Syst Pharm. 2015;72:1987-92.
McKaig D, Collins C, Elsaid KA. Impact of
Elsaid KA, Truong T, Monckberg M, McCarthy H, Butera J,
Recent Creative, Scholarly Work and Publications
Hurtig M, Zaghloul I, Sheardown H, Schmidt TA, Liu L, Zhang L, Elsaid KA, Jay GD. Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhPRG4 following ACL transection in the Yucatan mini pig. J Orthop. Res. 2019 Feb;37(2):386-396.
Qadri M, Almadani S, Jay GD, Elsaid KA. Role of CD44 in regulating TLR2 activation of human macrophages and downstream expression of proinflammatory cytokines. J Immunol 2018 Jan;200(2):758-767. DOI: 10.4049/jimmunol.1700713. [PMID: 29196459] [PMCID: PMC5760314].
Lefebvre AL, Zullo AR, Dappah-Afriyie R, Collins CM, Elsaid KA. Outcomes of a pharmacist-managed clinic for underserved persons with unmanaged type 2 diabetes mellitus. J Pharm Pract Res. 2018 Feb;48(1):65-71. DOI: 10.1002/jppr.1349.
Qadri M, Jay GD, Ostrom R, Zhang L, Elsaid KA. cAMP attenuates TGF-ß’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4. Am J Physiol Cell Physiol. 2018 Jun 13. DOI: 10.1152/ajpcell.00041.2018. [PMID: 29898378].
Qadri M, Jay GD, Zhang LX, Wong W, Reginato A, Sun C, Schmidt T, Elsaid KA. Recombinant human proteoglycan-4 reduces phagocytosis of urate crystals and downstream nuclear factor kappa b and inflammasome activation and production of cytokines and chemokines in human and murine macrophages. Arthritis Res Ther 2018 Aug 29;20(1):192. DOI: 10.1186/s13075-018-1693-x. [PMID: 30157934].
Elsaid KA, Ubhe A, Shaman Z, D’Souza G. Intra-articular interleukin-1 receptor antagonist (IL-1 ra) microspheres for posttraumatic osteoarthritis: in vitro biological activity and in vivo disease modifying effect. J Exp Orthop 2016;3(1):18.
Larson KM, Zhang LX, Elsaid KA, Schmidt TA, Fleming BC, Badger GJ, Jay GD. Reduction of friction by recombinant human proteoglycan-4 in IL-1a stimulated bovine cartilage explants. J Orthop Res 2017;35(3):580-589.
Alquraini A, Jamal M, Zhang L, Schmidt TA, Jay GD, Elsaid KA. The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes. Arthritis Res Ther 2017;19(1):89.