» Dr. Keykavous Parang
Professor, Associate Dean of Research, Graduate Studies and Global Affairs

School of Pharmacy
Schmid College of Science and Technology
Chemistry
Dr. Keykavous Parang
Office Location:
Rinker Health Science campus 262
Phone:
(714) 516-5489
Email:
Education
University of Tehran, Doctor of Pharmacy
University of Alberta, Ph.D.
Biography

Dr. Keykavous Parang is Associate Dean of Research, Graduate Studies and Global Affairs and a Full Professor in the School of Pharmacy at Chapman University.

Prior to joining the school, he joined the University of Rhode Island in October 2000. He became full professor there in July 2008.

He earned his Pharm.D. degree from Tehran University of Medical Sciences in 1989, and his Ph.D. in medicinal chemistry from the Faculty of Pharmacy at University of Alberta in 1997, followed by a postdoctoral study in the fields of carbohydrate chemistry and solid-phase organic synthesis in Department of Chemistry.

Dr. Parang’s research can be appropriately described as "the application of synthetic organic chemistry to problems in biology". Specific areas currently under investigation include (1) using peptides as cell-penetrating molecular transporters in drug delivery; (2) designing protein kinase inhibitors; (3) development of multifunctional anti-HIV, anticancer, and antibacterial agents; (4) synthesis and evaluation of modified nucleosides and nucleic acids; and (5) designing peptide nanomaterials for applications in drug delivery and tissue engineering. He is an author of 130 peer-reviewed publications, 7 patents, and 118 meeting abstracts.

Dr. Parang serves as editorial board member or editorial advisory board of several journals. Dr. Parang serves as a permanent member of Cancer Drug Discovery Peer Review Committee in American Cancer Society. He served as the Program Coordinator of Rhode Island IDeA Network of Biomedical Research Excellence (RI-INBRE) NIH program (June 2012-2013). He is a member of American Chemical Society, American Association for the Advancement of Science, American Association of Pharmaceutical Scientists, and American Association of Colleges of Pharmacy.

Dr. Parang has received numerous awards and honors, such as Outstanding Intellectual Property Development (URI, 2013), Research Excellence Award (College of Pharmacy, URI, 2012), Outstanding Researcher (URI, 2011), and Honorary Fellow of the Indian Society Chemists and Biologists (ISCB) (2009).

His research philosophy is to explore cutting edge areas of biomedical sciences through establishing national and international collaborations. He has initiated and established international collaboration with scientists in India, Germany, Puerto Rico and many other countries. He is currently an Adjunct Faculty in Department of Molecular Pharmacology, Physiology and Biotechnology at Brown University, a visiting scientist in Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, a research professor in Department of Biomedical and Pharmaceutical Sciences at the University of Rhode Island, and a member of Chao Family Comprehensive Cancer Center, University of California, Irvine.

Research Interests

Dr. Parang’s research can described as "the application of synthetic organic chemistry to problems in biology". Specific areas currently under investigation include (1) using peptides as cell-penetrating molecular transporters in drug delivery; (2) designing protein kinase inhibitors; (3) development of multifunctional anti-HIV, anticancer, and antibacterial agents; (4) synthesis and evaluation of modified nucleosides and nucleic acids; and (5) designing peptide nanomaterials for applications in drug delivery and tissue engineering. He is an author of 140 peer-reviewed publications, 7 patents, and 126 meeting abstracts.

Recent Creative, Scholarly Work and Publications
Nasrolahi Shirazi, A.; El-Sayed, N. S.; Tiwari, R. K.; Mandal, D.; Parang, K. Synthesis and biological evaluation of linear and cyclic peptides containing cysteine and arginine as a drug delivery system. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014, BIOL-237.
Oh, D.; Sun, J.; Nasrolahi Shirazi, A.; LaPlante, K. L.; Rowley, D. C.; Parang, K. Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug resistant pathogens. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014, MEDI-62.
Sayeh, N.; Nasrolahi Shirazi, A.; Tiwari, R. K.; Oh, D.; Parang, K. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014, MEDI-63.
El-Sayed, N. S.; Shirazi, A. N.; Tiwari, R. K.; Parang, K. Synthesis of conjugates of a cell penetrating cyclic peptide with paclitaxel and camptothecin. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014, MEDI-166.
El-Sayed, N. S.; Shirazi, A. N.; Tiwari, R. K.; Parang, K. Efficient solid-phase synthesis of iRGD analog containing a cysteine anchor as tumor homing peptide. 248th ACS National Meeting & Exposition, San Francisco, CA, United States, August 10-14, 2014, ORGN-278.
Parang, K., Peptide nanostructures as nolecular transporters of anticancer agents. Gordon Conference: Chemistry and Biology of Peptides, Ventura, CA, United States, February 23-28, 2014.
Shirazi, A., Tiwari, R., Parang, K. Cyclic peptide-capped selenium nanoparticles as nano drug delivery systems. Gordon Conference: Chemistry and Biology of Peptides, Ventura, CA, United States, February 23-28, 2014.
Nasrolahi Shirazi, A., Paquin, K. L., Howlett, N. G., Mandal, D., Parang, K. Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery. Molecules (2014), 19, 13319-13331
Oh, D., Nasrolahi Shirazi, A., Northup, K., Sullivan, B., Tiwari, R. K., Bisoffi, M., Parang, K. Enhanced cellular uptake of short polyarginine peptides through fatty acylation and cyclization. Mol. Pharmaceutics (2014) DOI: 10.1021/mp500203e.
Oh, D., Darwish, S. A., Nasrolahi Shirazi, A., Tiwari, R. K., Parang, K. Amphiphilic bicyclic peptides as cellular delivery agents. ChemMedChem (2014) DOI: 10.1002/cmdc.201402230.
Verma, A. K., Patel, M., Joshi, M., Likhar, P. R., Tiwari, R. K., Parang, K. Base-mediated chemo- and stereoselective addition of 5-aminoindole/tryptamine and histamines onto alkynes. J. Org. Chem. (2014) 79, 172-186.
Yoon, Y. K., Ali, M. A., Wei, A. C., Shirazi, A. N., Parang, K., Choon, T. S. Benzimidazoles as new scaffold of sirtuin inhibitors: Green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. Eur J Med Chem. (2014) 83C, 448-454.
Almansour, A. I., Kumar, R. S., Beevi, F., Shirazi, A. N., Osman, H., Ismail, R., Choon, T. S., Sullivan, B., McCaffrey, K., Nahhas, A., Parang K, Ali, M. A. Facile, regio- and diastereoselective synthesis of spiro-pyrrolidine and pyrrolizine derivatives and evaluation of their antiproliferative activities. Molecules (2014) 19, 10033-10055.
Muthyala, M. K. Velisetti, K., Parang, K., Kumar, A. K. Advances in functionalized ionic liquids as reagents and scavengers in organic synthesis. Current Org. Chem. (2014) in press.
Sayeh, N., Nasrolahi Shirazi, A., Oh, D., Sun, J., Rowley, D., Banerjee, A., Yadav, A., Tiwari, R. K., Parang, K.. Amphiphilic triazolyl peptides: Synthesis and evaluation as nanostructures. Current Org. Chem. (2014) in press.
Pemmaraju, B. P., Malekar, S., Agarwal, H. K., Tiwari, R. K., Oh, D., Doncel, G. F., Worthen, D. R., Parang,, K., Design, synthesis, antiviral activity, and pre-formulation development of poly-L-arginine-fatty acyl derivatives of nucleoside reverse transcriptase inhibitors. Nucleosides, Nucleotides and Nucleic Acids (2014) in press.
Choudhary, S., Muthyala, M. K., Parang, K., Kumar A. Ionic liquid-supported sulfonyl hydrazine: A useful reagent for traceless synthesis of pyrazoles. Frontiers in Organic Chemistry (2014) 1, 683-688.
Mandal, D., Nasrolahi Shirazi, A., Parang, K. Self-assembly of peptides to nanostructures. Org. Biomol. Chem. (2014) 12, 3544-3561.
Chand, K., Prasad, S., Tiwari, R. K., Shirazi, A. N., Kumar, S., Parang, K., Sharma, S. K. Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives. Bioorganic Chem. (2014) 53, 75-82.
Pemmaraju, B., Agarwal, H. K., Oh, D., Buckheit, K. W., Buckheit Jr. R. W., Tiwari, R., Parang, K. Synthesis and biological evaluation of 5'-O-dicarboxylic fatty acyl monoester derivatives of anti-HIV nucleoside reverse transcriptase inhibitors. Tetrahedron Lett. (2014) 55, 1983-1986.
Ghasemi Pirbalouti, A, Sajjadi, S. E., Parang, K. A Review (Research and Patents) on jasmonic acid and its derivatives. Arch Pharm (Weinheim). (2014) 347, 229-239.
Motavallizadeh, S., Fallah-Tafti, A., Maleki, S., Nasrolahi Shirazi, A., Pordeli, M., Safavi, M., Kabudanian Ardestani, S., Asd, S., Tiwari, R., Oh, D., Shafiee, A., Foroumadi, A., Parang, K., Akbarzadeh T., Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tet. Lett. (2014) 55, 373-375.
El-Sayed, N.S., Shirazi, N. A., El-Meligy, M. G., El-Ziaty, A. K., Nagib, Z. A., Parang, K. Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity. Tetrahedron Lett. (2014) 55, 1154-1158.
Yoon, Y. K., Ali, M., A., Wei, A. C., Choon, T. S., Osman, H., Parang, K., Shirazi, A. M. Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities. Bioorg. Med. Chem. (2014) 22, 703-710.
Oh, D., Sun, J., Nasrolahi Shirazi, A., LaPlante, K. L., Rowley, D. C., Parang, K. Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug resistant pathogens. Mol. Pharmaceutics (2014), in press.
Beni, Y. A.; Parang, K. Synthesis and thermal stability evaluation of six-membered cyclic triphosphates containing three nucleotides. 65th Southeast Regional Meeting of the American Chemical Society, Atlanta, GA, United States, November 13-16, 2013, SERM-204.
Parang, K. Peptide nanostructures as molecular transporters of anticancer agents. 16th Annual Chao Family Comprehensive Cancer Center Scientific Retreat, Palm Springs, CA, November 15-16, 2013.
Nasrolahi Shirazi, A., Parang, K. Cyclic peptide-capped selenium nanoparticles as molecular transporters. 246th ACS National Meeting & Exposition, Indianapolis, IN, United States, September 8-12, 2013, BIOL-147.
Nasrolahi Shirazi, A., Oh, D., Tiwari, R. K., Sullivan, B., Gupta, A., Bothun, G. D., Parang, K. Peptide amphiphile containing arginine and fatty acyl chains as molecular transporters. Mol. Pharmaceutics (2013) 10, 4717-4727.
Suresh, N., Nagesh, H. N., Sekhar, K., V. G. C., Kumar, A., Shirazi, A. N., Parang K. Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines. Bioorg. Med. Chem. Lett. (2013) 23, 6292-6295.
Shelke, G. M., Rao, V. K., Tiwari, R., Chhikara, B. S., Parang K., Kumar A. Bismuth triflate-catalyzed condensation of indoles with acetone. RSC Adv. (2013) 3, 22346-22352.
Pericherla, K., Poonam Khedar, P., Khungar, B., Parang, K., Kumar, A. Copper catalyzed tandem oxidative C–H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines. RSC Adv. (2013) 3, 18923-18930.
Mandal, D., Tiwari, R. K., Nasrolahi Shirazi, A., Ye, G., Banerjee, A., Yadav, A., Parang, K. Self-assembled surfactant cyclic peptide nanostructures as stabilizing agents. Soft Matter. (2013) 9. 9465-9475.
Pericherla, K., Nasrolahi Shirazi, Rao, A. V. K., Tiwari, R., DaSilva, N., Mccaffrey, K. T. Seeram, N., Parang, K., Kumar A., Synthesis and antiproliferative activities of Quebecol and its analogs. Bioorg. Med. Chem. Lett. (2013) 23, 5329-5331.
Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D., Sullivan, B., McCaffrey, K., Mandal. D., Parang, K. Surface decorated gold nanoparticles by linear and cyclic peptides as molecular transporters. Molecular Pharmaceutics. (2013) 10, 3137-3151.
Kumar, A., Rao, V. K., Tiwari, R., Chhikara, B. S., Shirazi, A. N., Parang, K. Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities. RSC Adv. (2013), 3, 15396-15403.
Chand, K.; Shirazi, A. N.; Yadav, P.; Tiwari, R. K.; Kumari, M.; Parang, K.; Sharma, Sunil K. Canadian Journal of Chemistry (2013) 91, 741-754.
Chand, K., Tiwari, R. K., Kumar, S., Shirazi, A. N., Sharma, S., Eycken, E. V. V. D, Parmar, V. S., Parang, K., Sharma, S. K. Synthesis, antiproliferative, and c-Src kinase inhibitory activities of chromone derivatives. J. Heterocyclic Chemistry (2013) DOI 10.1002/jhet.2106.
Kumar, A., Ye, G., Gu, X., Wang, Y., Sun, G., Parang K. Synthesis of pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their Src kinase inhibitory activities. Chemistry & Biology Interface (2013) 3, 264-269.
Kameshwara Rao V., Shelke, G. M., Tiwari, R., Parang, K., Kumar A. A simple and efficient synthesis of 2,3-diarynaphthofurans using sequential hydroarylation/Heck oxyarylation. Org. Lett. (2013) 15, 2190-2193.
Nasrolahi Shirazi, A., Tiwari, R. K., Brown, A., Mandal, D., Sun, G., Parang, K. Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors. Bioorg. Med. Chem. Lett. (2013) 23, 3230-3234.
Nasrolahi Shirazi, A., Tiwari, R. K., Oh, D, Banerjee, A, Yadav, A, Parang, K. Efficient delivery of cell impermeable phosphopeptides by a cyclic peptide amphiphile containing tryptophan and arginine. Mol. Pharm. (2013) 10, 2008-2020.
Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R., Parang, K., Spaller, M. R., Goebel, D. J., Marshall, J., Impairment of TrkB-PSD-95 signaling in Angelman syndrome, PLoS Biology, (2013) 11, e1001478.
Chand, K., Nasrolahi Shirazi, A., Yadav, P., Tiwari, R. K., Kumari, M., Parang K., Sharma, S. K. Synthesis, antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives. Can. J. Chem. (2013) 91, 741-754.
Nasrolahi Shirazi, A., Tiwari, R. K., Chhikara, B. S., Mandal, D., Parang, K. Design and evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. Molecular Pharmaceutics (2013) 10, 488-499.
Agarwal, H. K., Chhikara, B. S., Bhavaraju, S., Mandal, D., Doncel, G. F., Parang, K. Emtricitabine prodrugs with improved anti-HIV activity and cellular uptake. Molecular Pharmaceutics (2013) 10, 467-476.
Nasrolahi Shirazi, A., Mandal, D., Tiwari, R. K., Guo, L., Lu, W., Parang, K. Cyclic peptide-capped gold nanoparticles as drug delivery systems. Molecular Pharmaceutics (2013), 10, 500-511.