» Structural Biology Research Center (SBRC)

About

The Structural Biology Research Center (SBRC) is housed by the Chapman University School of Pharmacy (CUSP) in the Harry and Diane Rinker Health Science Campus, Irvine. The center offers expertise and access to the cutting-edge instrumentation for biomolecular structural analysis and drug development, including x-ray crystallography, NMR spectroscopy, and protein-ligand interaction analysis.

+ - Mission

Our mission at SBRC is to advance structure-based drug design and development by integration of structural and biophysical techniques for the characterization of structure and function of biomolecules and macromolecular complexes. To accomplish this mission, we aim to develop collaborations and partnerships with other academic institutions as well as Biotech and pharmaceutical companies. 

+ - Center Activities

SBRC provides training, access to the equipment, and any needed assistance in sample preparation, as well as X-ray diffraction, NMR, and SPR data collection and analysis.

SBRC Members

  • Dr. Simin Rahighi
  • Dr. Innokentiy Maslennikov
  • Dr. Miao Zhang

+ - Equipment

X-ray Crystallography

Mosquito Crystallization Robot (TTP Labtech. Inc)

  • High-throughput crystallization of biomacromolecules (soluble and membrane proteins, peptides)

D8 Venture Liquid Gallium Metaljet (Bruker)

  • X-ray diffraction data collection
  • X-ray diffraction data analysis and structure determination

Nuclear Magnetic Resonance (NMR)

Avance III HD 400 MHz (Bruker)

  • Solution NMR spectroscopy data collection (1H, 13C, 15N, 19F, 31P, etc.)
  • Small Molecule/Protein Characterization
  • Label-free detection of ligand-target interactions

Protein-Ligand Interaction Assay

Biacore S200 (GE Healthcare)

Biacore S200 Machine

  • Surface Plasmon Resonance (SPR)
  • Label-free detection of protein-protein or protein-ligand interactions

+ - Contact

  • X-ray Crystallography
    • Dr. Simin Rahighi
  • NMR Spectroscopy
    • Dr. Innokentiy Masslenikov