» Structural Biology Research Center (SBRC)

The Structural Biology Research Center (SBRC) is housed by the Chapman University School of Pharmacy (CUSP) in the Harry and Diane Rinker Health Science Campus, Irvine. The center offers expertise and access to the cutting-edge instrumentation for biomolecular structural analysis and drug development, including x-ray crystallography, NMR spectroscopy, and protein-ligand interaction analysis.

Our mission at SBRC is to advance structure-based drug design and development by integration of structural and biophysical techniques for the characterization of structure and function of biomolecules and macromolecular complexes. To accomplish this mission, we aim to develop collaborations and partnerships with other academic institutions as well as Biotech and pharmaceutical companies. 

Center Activities: 

SBRC provides training, access to the equipment, and any needed assistance in sample preparation, as well as X-ray diffraction, NMR, and SPR data collection and analysis.

SBRC Members:

  • Dr. Simin Rahighi - X-ray Crystallography
  • Dr. Innokentiy Maslennikov - NMR Spectroscopy
  • Dr. Miao Zhang - X-ray Crystallography
  • Dr. Gennady Verkhivker - Computational Biology

Equipment

+ - X-ray Crystallography

Mosquito LCP Equipment

Mosquito Crystallization Robot (TTP Labtech. Inc)

  • High-throughput crystallization of biomacromolecules (soluble and membrane proteins, peptides)

D8 Venture Liquid Gallium Metaljet (Bruker)

  • X-ray diffraction data collection
  • X-ray diffraction data analysis and structure determination

Metaljet

Stereo Microscope

Axiocam Erc

+ - Nuclear Magnetic Resonance (NMR)

Avance III HD 400 MHz (Bruker)Axiocam Erc

  • Solution NMR spectroscopy data collection (1H, 13C, 15N, 19F, 31P, etc.)
  • Small Molecule/Protein Characterization
  • Label-free detection of ligand-target interactions

+ - Protein-Ligand Interaction Assay

Biacore S200 (GE Healthcare)

Biacore S200 Machine

  • Surface Plasmon Resonance (SPR)
  • Label-free detection of protein-protein or protein-ligand interactions

+ - SBRC Pricing

For information regarding SBRC pricing, please click here to learn more.