Dr. Yang Liu
- Peking University, Bachelor of Science
Peking University, Master of Science
University of North Carolina at Chapel Hill, Ph.D.
Dr. Liu joined CUSP on Aug. 1st, 2015 as an Assistant Professor of Pharmaceutics and Biopharmaceutics. Dr. Liu obtained a bachelor’s degree from Peking University and a Ph.D. in molecular pharmaceutics from the University of North Carolina at Chapel Hill. Before joining the CUSP faculty, she was a postdoctoral fellow at UCLA California NanoSystems Institute.
The development of biopharmaceuticals (including recombinant proteins and nucleic acids) is of tremendous interest due to their high biological activity and specificity compared to small molecules. The formulation of biopharmaceuticals, however, poses a formidable challenge to their use in the clinic. Unmodified proteins and nucleic acids usually undergo rapid clearance after administration, unable to cross cellular barriers, and lose bioactivity during manufacturing and storage. My research focuses on the design and development of drug delivery systems for biopharmaceuticals to address these substantial challenges. The systems we study utilize a wide variety of lipid and polymer-based materials to manipulate release kinetics and in vivo behavior of the biopharmaceuticals.
Recent Creative, Scholarly Work and Publications
Liu Y, Lee J, Mansfield KM, Ko JH, Sallam S, Wesdemiotis C, Maynard HD*. Trehalose Glycopolymer Enhances Both Solution Stability and Pharmacokinetics of a Therapeutic Protein. Bioconjug Chem. 2017;28 (3):836-845.